Scientist I-Lipid Nanoparticle Formulation
Software Guidance & Assistance San Diego
Software Guidance & Assistance, Inc., (SGA), is searching for a Scientist I for a CONTRACT assignment with one of our premier Pharmaceutical clients in San Diego, CA.
Responsibilities:We seek an outstanding candidate to join the Gene Therapy Nanotechnology team. The Scientist I will contribute to our cutting-edge delivery platform by designing, preparing, and characterizing ligand conjugates and targeted lipid nanoparticles.
A critical component of this role is supporting targeted delivery systems through bioconjugation chemistry, including preparing protein conjugates and formulating targeted LNPs.
- Execute bioconjugations (e.g., antibodies, peptides) with small molecules or polymers.
- Validate and purify bioconjugates via LC-TOF and A KTA purification station.
- Formulate non-targeted and targeted LNPs encapsulating nucleic acids using microfluidic or T-junction mixing technologies.
- Perform surface bioconjugation for targeted LNPs.
- Support analytical assay development (BLI, fluorescence microscopy, A KTA).
- Evaluate ligand and particle stability under various conditions.
- Maintaining electronic laboratory notebooks.
- Authoring SOPs.
Required Skills:
- MS with 2+ years or BS with 5+ years in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or a related scientific discipline (an equivalent combination of education and experience may be considered).
- Proven experience with lipid nanoparticle formulation and LNP characterizations via RiboGreen, Dynamic Light Scattering (DLS), and Zeta potential measurement.
- Proficiency in bioconjugation and formulating buffers is required.
- Excellent attention to detail and ability to produce consistent results and effectively communicate with cross-functional teams.
- Proficiency in MS Excel is required; prior experience with advanced analytical software (Prism, JMP) is desirable.
- Excellent oral and written communication skills.
Preferred Skills:
- Extensive hands-on experience in bioconjugation methodologies, process optimization, and bimolecular reaction kinetics. Prior expertise in Antibody-Drug Conjugate (ADC) development is strongly preferred.
When we say let's work better together, we mean it. You'll join a diverse team built on these core values: customer service, employee development, and quality and integrity in everything we do. Be yourself, love what you do and find your passion at work.
Please find us at .
SGA is an Equal Opportunity Employer and does not discriminate on the basis of Race, Color, Sex, Sexual Orientation, Gender Identity, Religion, National Origin, Disability, Veteran Status, Age, Marital Status, Pregnancy, Genetic Information, or Other Legally Protected Status.We are committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, and our services, programs, and activities. Please visit our company to request an accommodation or assistance regarding our policy
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